Similarly, MZB caused accumulation of Cyt C and Smac in the cytosol of multiple myeloma cells [30], whereas lymphocytic leukemia cells and cervical cancer cells exposed to bortezomib and delanzomib showed marked overexpression of Noxa, which contributed to the apoptotic death of these cells [37,38]. Here, PMAIP1 is linked to AL amyloidosis.