CCN2 and gingival overgrowth: There were significant differences in the expressed levels of connective tissue growth factor (CTGF) between the group of patients taking amlodipine who developed gingival enlargement compared to the patients taking amlodipine without gingival enlargement, as well as between the patients not taking amlodipine that had gingival enlargement and the patients taking amlodipine without gingival enlargement (Figure 3).