The lower cytokine expression levels observed in patients using amlodipine, particularly those with gingival enlargement, may be explained by previous findings showing increased IL-33 expression during the advanced or stable phase of periodontal disease when a Th2 inflammatory response dominates, probably due to IL-33’s profibrotic role [27,28,29,30]. The gene discussed is IL33; the disease is gingival overgrowth.