For example, L. plantarum WLPL21 showed the best mitigatory effect on HCD-induced hypercholesterolemia, including upregulating cholesterol metabolism (CYP27A1, CYP7B1, CYP7A1, and CYP8B1) levels in the liver, cholesterol transportation (ABCA1, ABCG5, and ABCG8) in the ileum or liver, and downregulating NPC1L1 [134] (Table 1). The gene discussed is CYP7A1; the disease is familial hypercholesterolemia.