TNF and inflammation: It has been demonstrated that Resolvin D1 can attenuate neutrophil infiltration, reduce pro-inflammatory cytokines, and enhance alveolar macrophage function in ARDS and acute lung injury, while 14-HDHA has shown efficacy in reducing inflammation in the lungs by decreasing inflammatory cytokines such as TNF-α, IL-6, and MCP-1, which are crucial markers of lung inflammation [48,49].