The development of hypertension and salt sensitivity and the activation of purinergic receptors can be summarized as follows: in situations of hyperactivity of the sympathetic nervous system, overstimulation of the renin–angiotensin system, or a genetic predisposition, some stress situations may induce a temporary elevation in blood pressure (11, 65, 66). The gene discussed is P2RX4; the disease is Hypertension.