The study by Sun et al. [150] demonstrated, for the first time, that the portal infusion of adeno-associated viral vectors expressing antisense HIF1-α downregulated HIF-1α and its downstream effectors, including VEGF, glucose transporter 1 (GLUT1), and LDHA, and enhanced the inhibitory effect of TAE on the growth of HCC in rats. Here, HIF1A is linked to hepatocellular carcinoma.