CDH1 and neoplasm: Hypoxia contributes to tumor cell detachment, adhesion, and migration by downregulating the expression of epithelial cadherin (E-cadherin) [39,40], upregulating the expression of integrin genes [41], stimulating the release of matrix metalloproteinase (MMP)-2 [42] and the urokinase plasminogen activator (uPAR) [43], and inducing the production of autocrine motility factors (AMFs) such as hepatocyte growth factor (HGF) [43,44,45].