Huang’s research team discovered through preliminary analysis that the BicC family RNA-binding protein 1 (BICC1) gene was overexpressed in human pancreatic cancer, and subsequently utilized xenotransplanted tumor cells and mice to confirm that BICC1 plays a pivotal role in the VEGF-independent angiogenesis process in pancreatic cancer, resulting in resistance to VEGF inhibitors and offering novel therapeutic targets for pancreatic cancer patients [116]. Here, VEGFA is linked to familial pancreatic carcinoma.