These include conditional knockout models for tumor suppressor genes like P53 and Phosphatase And Tensin Homolog (PTEN) using P53 Flox and PTEN Flox mice [103,104], and point mutation (or conditional point mutation) cancer models for oncogenes such as the Kras-LoxP-Stop-LoxP (LSL)-G12D model [105,106]. The gene discussed is TP53; the disease is cancer.