Revskij et al. used the Uncoupling Protein 2 knockout (Ucp2 KO) mouse model to explore the effect of Ucp2 on the microenvironment of pancreatic ductal adenocarcinoma (PDAC) [60], while Han et al. focused on the application of humanized immune system (HIS) mouse model in Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T) therapy [61]. Here, UCP2 is linked to pancreatic ductal adenocarcinoma.