A similar diagnostic approach to optic neuropathy applies here, including testing for ANA, aPL, anti-ribosomal P protein, anti-Ro60/SSA, anti-La/SSB, anti-aquaporin 4 (AQP4), anti-myelin oligodendrocyte glycoprotein (MOG), and ANCA. Here, AQP4 is linked to Optic neuropathy.