EGF and cancer: Moreover, it was reported that specific GRB7 peptides targeting the SH2 domain of GRB7 blocks EGF/EGFR signal-mediated ERK activation [8] and deletion of GRB7 ablates MMP-9 expression in cervical cancer [28], which suggest that GRB7 may modulate cancer invasion by mediating EGF/EGFR signal-mediated ERK activation or matrix metallopeptidase 9 (MMP-9) expression.