Treatment of tumor-bearing mice with either 40 kBq [225Ac]Ac-PSMA-617 alone or a combination of 20 kBq [225Ac]Ac-PSMA-617 and 17 MBq [177Lu]Lu-PSMA-617 was found to significantly enhance overall survival of the mice, irrespective of the tumor size at the start of the treatment. Here, FOLH1 is linked to neoplasm.