LMNA and familial dilated cardiomyopathy: Since the mouse model is more similar to humans, has a relatively short life span (1–2 years), and is easily manipulated, a number of studies have generated an LMNA A/C variant mouse model to mimic the phenotype of LMNA A/C-related DCM and to determine the pathogenic role of the LMNA gene in DCM shown on Table 3.