Similarly, in LMNA p.N195K variant mice, the disease phenotype of laminopathy or dilated cardiomyopathy was not observed in the heterozygous LMNA p.H222P variant mice; nonetheless a severe disease phenotype of LMNA-related DCM was evident when homozygote mice reached adulthood [40]. Here, LMNA is linked to familial dilated cardiomyopathy.