As shown in Figure 2, the pathogenesis of DCM with conduction system abnormalities in laminopathies is likely multifaceted and includes disrupted chromatin modelling, abnormal activation of mitogen-activated protein kinase (MAPK) and TGF-β-related pathways, and altered calcium loading related to LMNA variants. This evidence concerns the gene LMNA and familial dilated cardiomyopathy.