However, hypertension, arrhythmology, myocardial infarction, hypercholesterolemia, dehydration, hypokalemia, pneumonia, upper respiratory tract infection, urinary and genital tract infections, headache, alanine aminotransferase increased, hepatic steatosis, tinnitus and otitis media, etc., which were listed on the drug label, did not show positive signals. This evidence concerns the gene GPT and hypertensive disorder.