The results of a previous study in the 3×Tg-AD mouse model showed that TBN markedly improved cognitive function through a reduction in the Aβ levels and plaque deposition, tau hyperphosphorylation, and the restoration of synaptic function, which was likely associated with the inhibition of APP, BACE1, and PS1 protein expression [22]. This evidence concerns the gene BACE1 and Alzheimer disease.