CHRM2 and myocardial ischemia: Furthermore, the action of WXKL may reduce the QT interval and dawdle the heart rate by downregulating sodium channel protein type 5 subunit alpha (SCN5A) and the beta-2 adrenergic receptor (ADRB2) and upregulating muscarinic acetylcholine receptor M2 (CHRM2) during myocardial ischemia.