Other diseases apart from AD that could benefit from increased neurotrophin signaling include Parkinson’s disease [187], Huntington’s disease [188], SLE [43], MS [43,44], neuropsychiatric diseases [70], TBI [41,121], CMT1A [129,130], and inflammatory diseases such as osteoarthritis [30,42], but also other types of diseases with reduced neurotrophic support such as acquired hearing loss [189]. This evidence concerns the gene BDNF and osteoarthritis.