The increased expression of osteoclast transcription factors such as a nuclear factor of activated T cytoplasmic 1 cell (NFATc1/c-Fos), RANKL activates nuclear factor κB (NF-κB), macrophage colony-stimulating factor (MCSF), c-Jun N-terminal kinase (JNK), extracellular regulated kinases (ERK) and p38 can lead to osteoporosis [70]. This evidence concerns the gene FOS and osteoporosis.