Recent studies suggest that NAR may have a potential effect on controlling the proliferation, invasion, and metastasis of different malignancies, such as colon cancer, lung neoplasms, breast cancer, leukemia and lymphoma, pancreatic cancer, liver cancer, brain tumors, melanoma, and cervical and ovarian cancer [21,44,45]. The gene discussed is CPSF4; the disease is malignant colon neoplasm.