Recent studies suggest that NAR may have a potential effect on controlling the proliferation, invasion, and metastasis of different malignancies, such as colon cancer, lung neoplasms, breast cancer, leukemia and lymphoma, pancreatic cancer, liver cancer, brain tumors, melanoma, and cervical and ovarian cancer [21,44,45]. Here, CPSF4 is linked to familial pancreatic carcinoma.