It should be kept in mind that even moderate long-term prolactin excess, irrespective of gender, predisposes to insulin resistance, prediabetes, atherogenic dyslipidemia, excessive and/or subnormal fat accumulation, subclinical atherosclerosis, and endothelial dysfunction [15,16,17,18,19,20], and therefore, it should be avoided. This evidence concerns the gene PRL and prediabetes syndrome.