Conversely, in the A2.DR1 mouse model, MVA-spCTH522 vaccination may help elucidate the role of CD4+ and CD8+ T-cell responses, while MVA-CTH522:B7 may determine whether the combined involvement of CD4+ T cells, CD8+ T cells, and antibody responses is critical for protection against infection. The gene discussed is CD80; the disease is infection.