As far as the phenotype of Ag+ T cells was concerned, in particular, their differentiation in terms of Th1, Th0/2, Th17, and circulating follicular helper (Tfh) cells, 143,403 CD4+ Ag+ T cells, obtained from MS patients and HD, were used for the unsupervised analysis. This evidence concerns the gene RENBP and myeloid sarcoma.