Based on the first two PCs (PC1 that accounted for 16.4% and PC2 that accounted for 10.1% of variance), PCA revealed that only MS patients, independently of their form of disease and age, differed for the Ag+ immune response when compared to age-matched HD (HD_RR vs. RR and HD-PR vs. PR), shaping two separate clusters (Figure 6A). The gene discussed is RENBP; the disease is myeloid sarcoma.