CD4 and common variable immunodeficiency: However, vaccination, according to the results of our work, did not statistically significantly lead to changes in lymphocyte parameters (CD45+CD3−CD19+, CD45+CD3+CD19−, CD45+CD3+CD4+, CD45+CD3+CD8+, CD45+CD3+CD16+CD56+); there was only an increase in relative counts (%) of CD45+CD3+CD19-lymphocytes and a decrease in relative counts (%) of CD45+CD3−CD19+ lymphocytes in the group of patients vaccinated with one dose, which is not confirmed by the data obtained in patients with CVID vaccinated with two doses.