Remarkably, it presents a particular challenge; it has been reported that differently to the vast majority of RNA viruses, the separation between spike proteins in SARS-CoV-2 is around 25 nm, far from the 5–10 nm needed for enhanced immune activation, since epitope repetition boosts immunogenicity [4,5,6], which might explain the inefficient and short-lived neutralizing antibody responses after vaccination and infection with SARS-CoV-2 [44], highlighting the importance of structure in antigen presentation. This evidence concerns the gene CHMP5 and infection.