In addition, because of the inter-relationship between the glycolysis-FA cycle and ferroptosis (Supplementary Figure S1), an iron-dependent mechanism of cell death that is thought to exacerbate liver inflammation and fibrosis preceding HCC development [35], expression of the GPX4 liver enzyme and the ferroptosis marker PRX3-SO2/3 [36], was also analysed. Here, GPX4 is linked to hepatocellular carcinoma.