Similar to other studies examining the relationship between physical activity and nutritional interventions with metabolic changes such as: insulin resistance index or cholesterol; alterations in cardiovascular risk factors, such as hypertension; and BMI or weight reduction [44,45], participants in the intervention group demonstrated a reduction in percentage and kg of body fat [mean: −2.50 kg (CI 95%: −3.56, −1.44)] and percentage of fat-free mass [mean: −3.38% (IC 95%:−4.34, −2.41), accompanied by a marked increase in kg of muscle [mean: 1.09 (CI 95%: 0.41, 1.78)] in the posttest. The gene discussed is INS; the disease is Hypertension.