Those changes include the activation states of “Reelin Signaling in Neurons”, “Ephrin Receptor Signaling”, “Semaphorin Neuronal Repulsive Signaling Pathway”, and “Glutamate Receptor Signaling” and the inhibition states of “Netrin Signaling”, “Neuropathic Pain Signaling in Dorsal Horn Neurons”, “Oxytocin in Brain Signaling Pathway”, “Synaptic Long-term Potentiation”, and “Synaptic Long-term Depression”. The gene discussed is OXT; the disease is major depressive disorder.