A second analysis carried out in APPsw AD Tg2576 transgenic mice treated with a low dose of curcumin (160 ppm) or a high dose (5000 ppm) showed declines in the levels of IL-1β and oxidized proteins, a 16.5% decrease in an astrocyte marker—glial fibrillary acidic protein (generally elevated in inflammatory conditions)—and 39.2% × 43% of insoluble and soluble Aβ levels in the entorhinal cortex and hippocampus. The gene discussed is IL1B; the disease is Alzheimer disease.