In a mouse model of AD, supplementation with 200 mg/kg of curcumin promoted a decrease in neurofibrillary degeneration and loss of hippocampal neurons, as well as a decline in Bax levels and an increase in Bcl-2 rates (decrease in apoptosis with a blockade of cytochrome c release from mitochondria) [179]. Here, CYCS is linked to Alzheimer disease.