An interesting study showed that, on sepsis-induced cardiac dysfunction, curcumin can activate sirtuin 1 (SIRT1), elevate the expression of mitochondrial biogenesis-related genes Nrf2, Pgc1α, and Tfam, reduce dynamin-related protein 1 transport to mitochondria, and restore mitochondrial morphology and function in heart cells [101]. Here, PPARGC1A is linked to Sepsis.