GSK3B and Alzheimer disease: Thota et al. [296] examined the effects of administering 180 mg/day of curcumin on the insulin resistance of a group of people at high risk of developing DM2, and it was demonstrated that curcumin showed an improvement in insulin resistance index in the lipid profile, fasting insulin, GSK-3β, and islet amyloid polypeptide, the last two being important markers of AD.