As analyzed in a group of male C57BL/6 J mice in an AD model, the use of 150 mg/kg of curcumin improved spatial learning and spatial working memory and led to a decrease in lesions and apoptosis of neural cells; in addition, the deposition of Aβ1–42 and neuroinflammation were significantly reduced, reducing the levels of TNF-α, IL-6, IL-1β, and MDA, and augmenting the levels of superoxide dismutase and activation of the AMPK pathway [189]. This evidence concerns the gene TNF and Alzheimer disease.