Using 100 mg/kg of curcumin one hour before treatment with cisplatin (an important chemoattractant that can lead to cognitive impairment) in C57BL/6 mice showed that the autophagy caused by cisplatin was induced through the transcription factor 4/protein kinase B/the mammalian target of the rapamycin (ATF4-Akt-mTOR) signaling pathway by endoplasmic reticulum stress. This evidence concerns the gene ATF4 and Cognitive impairment.