Thereby, supplementation with Epigallocatechin-3-Gallate showed beneficial effects on circadian misalignment, obesity, insulin resistance, and lipid metabolism by normalizing the expression of the clock genes CLOCK and BMAL1, while resveratrol normalizes the rhythm of CLOCK and PER2 in addition to BMAL1 in animals fed an obesogenic diet [52,53]. The gene discussed is PER2; the disease is obesity due to melanocortin 4 receptor deficiency.