CD36 and obesity due to melanocortin 4 receptor deficiency: In particular, in human dysfunctions which are associated with high cardiovascular risk, including obesity, Ox-LDLs are able to induce platelet activation through CD36 binding, and 8-epi-PGF2α leads to platelet aggregation via thromboxane (TX) A2 receptors (TP), releasing adenosine diphosphate (ADP) [71].