In addition, orientin has been reported to exhibit significant anti-migratory and anti-invasive activities, along with down-regulation of MMP-9, in MCF-7 breast cancer cells even at a low concentration of 5 μM (showing approximately 40% inhibition) [38], which is higher than but still relevant to the estimated concentration of orientin in RTE used in our invasion and migration study (2.4 μM orientin in 100 μg/mL RTE, Figure 5 and Figure 7). Here, MMP9 is linked to breast carcinoma.