Our study showed an additional adverse effect of 2-OG that stimulated de novo lipogenesis since in cultured hepatocytes, as well as in the experimental rat model of hepatic steatosis, 2-OG was shown to increase ChREBP and SREBP1 concentrations, which are transcription factors that regulate the expression of lipogenic genes [32]. This evidence concerns the gene SREBF1 and Hepatic steatosis.