PKD1 and autosomal dominant polycystic kidney disease: The upregulation of glycolytic markers was confirmed in studies from subsets of human microarray data and cystic kidneys of Pkd1 mutant mice [11] while the TAME-PKD trial was the first evidence of human urine samples supporting the finding that increasing ADPKD severity is associated with a metabolic shift toward increased aerobic glycolysis [12].