In light of previous studies, the current study was designed to assess the preventive effects of puerarin on the onset and progression of hypertension and to verify the hypothesis that puerarin alleviates blood pressure by inhibiting the ROS/TLR4/NLRP3 inflammasome signaling pathway in the PVN of salt-induced prehypertensive rats. Here, TLR4 is linked to hypertensive disorder.