Regarding the inflammatory markers, patients with high-virulence PJIs had higher CRP (medians: 18.0 vs. 3.8 mg/L; p < 0.001) and ESR levels (medians: 37.0 vs. 25.0 mm/h; p = 0.002) compared to those without infections (Table 2). This evidence concerns the gene ESR1 and infection.