Faced with this new window on a possible relationship between periodontal disease and gastric infection by Hp, which is not yet well understood, possible questions emerge, such as whether: (1) the dental plaque supra and subgingival is a reservoir for Hp, (2) periodontal disease contributes to the increased presence of this bacterium in the oral cavity, (3) there is a relationship between Hp-induced gastric infection and the positive presence of this bacterium in the biofilm of periodontal patients, (4) the periodontal condition increases the risk of gastric infection from Hp. Here, HP is linked to periodontal disorder.