Li et al. found that adrenergic receptor alpha-1B (ADRA1B), muscarinic acetylcholine receptor M1 (CHRM1), ACHE, and monoamine oxidase B (MAOB) might be the important targets for the treatment of AD, and they may synergize to treat AD by regulating calcium balance, cholinergic balance, and phosphorylation. This evidence concerns the gene CHRM1 and Alzheimer disease.