APP and Alzheimer disease: Wang et al. found that AOF might play a significant role in improving AD by acting on targets such as amyloid precursor protein (APP) and transcription factor AP-1 (JUN) via the combined action of active ingredients such as chrysin, stigmasterol, and protocatechuic acid, and the activated astrocytes can promote the expression of the targets in the pathway of advanced glycation end product (AGE)-receptor for AGE (RAGE) or interleukin 17 (IL-17) [43].