CASP3 and Alzheimer disease: It was confirmed that the compound 2β-hydroxy-delta-cadinol (HOC) extracted from AOF had neuroprotective effects on Aβ-induced AD model mice and that HOC attenuated Aβ1-42-induced caspase-3 activation by inhibiting Aβ1-42-induced ROS production, which was able to inhibit caspase-3 activity [42].