Studies have shown that the treatment of DN by the AOF–Lindera aggregata (AOLA) herb pair were related to the regulation of cellular autophagy [104], and its mechanism was to promote the autophagy of podocytes through the modulation of the PI3K/Akt/mTOR signaling pathway to improve the renal pathological damage, thus exerting a therapeutic effect for the treatment of DN (Table 6) [105]. The gene discussed is AKT1; the disease is liver dysplastic nodule.