Li et al. found that adrenergic receptor alpha-1B (ADRA1B), muscarinic acetylcholine receptor M1 (CHRM1), ACHE, and monoamine oxidase B (MAOB) might be the important targets for the treatment of AD, and they may synergize to treat AD by regulating calcium balance, cholinergic balance, and phosphorylation. The gene discussed is ACHE; the disease is Alzheimer disease.