Yoo et al. reported that nootkatone, an active extract of AOF, had an inhibitory effect on colorectal cancer cells; the mechanism of the antiproliferative activity of nootkatone might be related to the increase in the transcriptional expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) by EGR-1 and the degradation of cyclin D1 through a mechanism related to the proteasomal degradation pathway [89]. Here, GDF15 is linked to colorectal cancer.