HMOX1 and Alzheimer disease: Bian et al. certified that oxyphylla A ameliorated cognitive deficits and reduced the expression levels of amyloid precursor protein (APP) and Aβ in AD mice, which exerted its antioxidant effects by the Akt-GSK3β and erythroid-derived 2-related factor 2 (Nrf2)- Keleh-like ECH-associated protein (Keap1)-heme oxygenase-1 (HO-1) pathways [38].