MAPK8 and cerebral infarction: Cheng et al. showed that the extracts of AOF ameliorated cerebral infarction in model rats by a mechanism concerned with the downregulation of JNK-mediated TLR4/tumor necrosis factor receptor-associated factor 3-interacting JNK-activating modulator (T3JAM) and ask1-associated inflammatory signaling pathways [56].