Genetic fusions involving anaplastic lymphoma kinase (ALK), neurotrophic receptor tyrosine kinase 1 (NTRK1), ROS proto-oncogene 1 (ROS1), rearranged during transfection (RET), and B-Raf proto-oncogene serine/threonine kinase (BRAF) genes are frequently observed in this type of melanoma. The gene discussed is ALK; the disease is melanoma.