In the past five years, studies have mainly reported the anticancer effects of artemisinin and its derivatives on breast cancer, lung cancer, liver cancer, and colon cancer, including inhibiting cell proliferation and metastasis, suppressing angiogenesis, promoting cell cycle arrest, inducing cell death, inhibiting glycolysis, targeting the STAT3 pathway and CSCs, and regulating immunity. Here, STAT3 is linked to malignant colon neoplasm.