In colon cancer, artemisinin exhibited anti-proliferation effects by inhibiting the expression of miR-22 and CyclinD1 [44], and when combined with 5-fluorouracil, artemisinin improved its effects on inhibiting proliferation and migration in colon cancer cells via PI3K/Akt signaling [45]. The gene discussed is CCND1; the disease is malignant colon neoplasm.