After the knockdown of activating transcription factor 4/6 or X-box binding protein 1 (XBP1), the induction effect of dihydroartemisinin on cancer cell ferroptosis, as well as the activity of CHAC1, was weakened, indicating that dihydroartemisinin could induce ferroptosis by upregulating CHAC1 via UPR [39]. This evidence concerns the gene XBP1 and cancer.