AKT1 and malignant colon neoplasm: Dihydroartemisinin inhibited the proliferation and metastasis of breast cancer by downregulating the TGF-β1/Smad signaling pathway and CIZ1 expression [16], inhibiting the growth and migration of human lung cancer cells by downregulating the PRIM2/SLC7A11 axis [25], inhibiting fibronectin-1 and integrin-β1 expression via the PI3K-Akt pathway [37], and inhibiting the proliferation, colony formation, and invasiveness of colon cancer cells by inhibiting NRP2, N-cadherin, and Vimentin expression [46].