Lonicera japonica polysaccharide, Poria cocos polysaccharide, Polygonatum sibiricum polysaccharide, Ganoderma lucidum polysaccharide, and Angelica sinensis polysaccharide can regulate NLRP3 to treat depression, neuroinflammation, liver injury, and chronic renal failure diseases, as shown in Figure 4. Here, NLRP3 is linked to depressive disorder.