Huang Hong et al. reported that Codonopsis pilosula polysaccharide (CPP) could alleviate herpes simplex virus encephalitis (HSE), and 100 mg/kg CPP significantly increased the expression of p-AKT, AKT, p-GSK3β, and GSK3β in the brain tissues of HSV-I mice and decreased the serum levels of IL-1β, NO, MDA, ROS, IFN-γ, and S-100B, as well as the viral titers in the brain, liver, and lung tissues. This evidence concerns the gene AKT1 and herpes simplex encephalitis.