In addition, YE R et al. reported that EUP-SeNP, a complex of 170 nM Eucommia ulmoides polysaccharides and selenium nanoparticles, could significantly reduce the release of IL-1β, IL-6, IL-12, IL-17, and TNF-α in mice with DSS-induced colitis and in LPS-stimulated IEC-6 and Caco-2 cells. This evidence concerns the gene TNF and colitis.