With decreasing molecular weight, Ganoderma lucidum polysaccharide (GLP), which also has a triple helix structure, can significantly reduce the expression of TNF-α, IL-1β, and IL-6 in the colon tissues of mice with DSS-induced ulcerative colitis and enhance the inhibition of L-selectin and ligand binding [135]. Here, IL6 is linked to ulcerative colitis.