However, 50, 100, and 200 mg/kg SGP-1-1 can significantly inhibit the expression of TLR4 and NF-κB p65 mRNA in the kidneys of DN mice and stimulate the production of SOD, thus reducing the release of IL-6, TNF-α, and MDA and alleviating the damage caused by inflammation and oxidative stress in DN mice [38]. Here, TLR4 is linked to liver dysplastic nodule.