Aerobic training and treatment with Lycium barbaru polysaccharide (LBPs) at a dose of 50 mg/kg reduced IL-6, IL-1β, and TNF-α release from plasma and TLR4, MyD88, p38MAPK, and p-NF-κB p65 expression in the liver tissues of NAFLD rats; downregulated intestinal-derived lipopolysaccharide and hepatic lipopolysaccharide-binding protein expression; and increased ZO-1 and occludin expression, exerting hepatoprotective effects [23]. Here, IL1B is linked to metabolic dysfunction-associated steatotic liver disease.