SOD1 and type 2 diabetes mellitus: Zhang Huazhi et al. reported that 50, 100, and 200 mg/kg Hedysarum polybotrys polysaccharide (HPS) could enhance the SOD and GSH-PX activities in the myocardial tissue of db/db mice with type 2 diabetes in a dose-dependent manner and upregulate the mRNA and protein expression of PPARγ, GLUT-4, and MMP2.