NLRP3 and major depressive disorder: However, Shi et al. reported that 20 and 80 mg/kg Poria cocos polysaccharide (PPS) significantly reduced the levels of IL-1β, IL-18, and TNF-α in the hippocampus of mice with LPS-induced depression and downregulated the expression of CD16/32, NF-κB p65, NLRP3, ASC, and cleaved caspase-1.