TGFB1 and Hepatic fibrosis: XIAO J et al. reported that Lycium barbarum polysaccharide (LBPs) had potential protective effects on liver injury in HFD-induced NAFLD rats, and experiments showed that a 1 mg/kg dose of LBPs significantly reduced fat deposition, inflammation, and ALT levels in rat livers; significantly reduced the levels of iNOS, COX-2, IL-1β, SOCS-3, TGF-β1, and α-smooth muscle actin (a-SMA) mRNAs and TGF-β1 and CYP2E1 protein levels in liver tissue; and inhibited JNK/c-Jun phosphorylation, thus improving liver fibrosis and alleviating oxidative stress-induced liver injury [62].