IL6 and Hepatic failure: Moreover, WANG K et al. reported that compared with pretreatment, a 6 mg/kg dose of Angelica sinensis polysaccharide (ASP) significantly reduced ALT and AST levels, as well as the levels of TNF-α, IFN-γ, IL-2, IL-6, MDA, and ROS, in the liver of ConA-induced mice and increased SOD activity to alleviate oxidative stress; at the same time, ASP inhibited the phosphorylation of proteins related to IL-6/STAT3 signaling and the phosphorylation of NF-κB signaling pathway-related proteins to reduce hepatic inflammatory injury and alleviate liver failure [112].