In vitro studies demonstrated the double role of SFN against CRC: on the one hand, it reduced SW480, DLD1, and HCT116 cell growth by modulating the Wnt/β-catenin pathway with an antitumoral effect [104]; on the other hand, as a phytoantioxidant compound, it protected CRC cells from oxidative stress, activating the Nrf2-mediated cytoprotective mechanism [105]. The gene discussed is SFN; the disease is colorectal carcinoma.