MMP9 and neoplasm: Resv was an effective chemosensitizer agent for CRC [99]; in addition, it chemosensitized 5-FU-resistant HCT116 cells, inducing caspase-3-dependent apoptosis; it strongly suppressed TNF-β-induced activation of tumor-promoting factors (as NF-κB, MMP-9, and CXCR4) and epithelial-to-mesenchymal transition factors (increased vimentin and slug, decreased E-cadherin).