Berberine (196) was found to activate the Silent Information Regulator-1 (SIRT1) signaling pathway following myocardial ischemia/reperfusion, as well as the Janus kinase 2/signal transducer and activator of transcription (JAK2/STAT3) signaling pathway, leading to reduced apoptosis and oxidative stress. The gene discussed is JAK2; the disease is myocardial ischemia.