SQSTM1 and colorectal carcinoma: The current study showed that sertraline remarkably augmented paclitaxel-induced autophagy by increasing autophagosome formation indicated by elevated LC3-II/I ratio and promoting autophagic flux by degrading autophagy cargo receptor SQSTM1/p62 (Figure 3), which may explain the synergistically cytotoxic effect of sertraline and paclitaxel combination therapy on CRC cells.