WWP1, CARM1, RASGRP1, THBS1, KCTD5, SGCA, EIF3S6, MCAM, FXR2, MTMR3, SOCS3, SLC2A4RG, THBS1, MMP2, MMP9, HSP47, PAI1, TIMP1, TGIF, COL6A1, AAK1, MAN1A1, NT5C2, IRS2, CSEN, C4BPA, PSG1, ALAD, FGD1, TFAP2B, MIDORI, AHCYL1, HSPG2, IL1RAP, and MAN1A1 TGF-β responsive genes have been determined in A549 (lung adenocarcinoma) and HPL1D (lung epithelial cell line) [10], but the same genes have not been analysed in HER2-positive trastuzumab resistant cell lines. The gene discussed is IL1RAP; the disease is lung adenocarcinoma.