Down-regulation of AGAP1 (ArfGAP With GTPase Domain, Ankyrin Repeat, and PH Domain 1, 608651) in neo-hypoplastic left heart syndrome and up-regulation of such a gene in HF-hypoplastic left heart syndrome revealed the different effects of such gene during the pathogenesis of different CHD subtypes [64]. The gene discussed is AGAP1; the disease is hydrops fetalis.