PDE3A (Phosphodiesterase 3A, 123805) together with PDE4 (Phosphodiesterase 4A, 600129) has been shown to control the intracellular cAMP and cardiac excitation–contraction coupling, which were further confirmed to be associated with Tetralogy of Fallot [82], validating our prediction. Here, PDE4A is linked to Tetralogy of Fallot.