Furthermore, in severely hemorrhagic patients experiencing low-flow states leading to traumatic cardiac arrest, tests such as NephroCheck®, which measure urinary biomarkers of damage [Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) and Insulin-like Growth Factor Binding Protein-7 (IGFBP-7)], can detect and predict AKI within just 3 h of ischemic shock, particularly in trauma cases [18]. The gene discussed is TIMP2; the disease is acute kidney injury.