Gene polymorphisms of the renin-angiotensin-aldosterone system (RAS), aldosterone synthase gene (CYP11B2), ATPase plasma membrane Ca2+ transporting 1 gene (ATP2B1), and endothelial nitric oxide gene polymorphisms have been studied and associated with an increased risk for hypertension [10]. The gene discussed is CYP11B2; the disease is hypertensive disorder.