In the COVID + kidney failure group, hepatocytes exhibited higher levels of cell–cell communication compared to other cell types (Figure 8D), with more active LAMC1–integrin and FN1–integrin interactions in hepatocyte-to-cholangiocyte and hepatocyte-to-fibroblast interactions (Figure 8E), indicating extracellular matrix modeling and cell migration. This evidence concerns the gene FN1 and kidney failure.