Our results indicated that in the codominant model, the heterozygosity CXCR2-CA genotype was correlated with an increased risk of PCOS, with an odds ratio of 1.91 (95% CI = 1.08–3.37), RR = 1.42 (1.0743 to 1.886), p < 0.024. This evidence concerns the gene CXCR2 and polycystic ovary syndrome.