Common hormone deficiencies associated with pituitary apoplexy include ACTH, TSH, gonadotropin (LH and FSH), GH, prolactin, and ADH deficiency, which may lead to fatigue, weakness, weight gain or loss, irregular or absent menstrual periods, infertility, growth retardation, diabetes insipidus, and secondary life-threatening situations. This evidence concerns the gene POMC and neurohypophyseal diabetes insipidus.