GSR and epilepsy: However, since the observed differences in oxidative stress markers (endogenous antioxidant enzyme activities of SOD, CAT, GPx, and GR, as well as markers of oxidative damage such as PC and NO metabolism—NO3− + NO2− concentration) between the polytherapy group and the group treated with old generation ASMs were confirmed, these results support the additional influence of ASM therapy on oxidative stress markers in addition to epilepsy itself.