This immune response, mediated through the TME, involves CD4+ T cells, CD8+ T cells, and NK cells, which are directly hindered not only by tumor cells but also by immunosuppressive regulatory T cells (Tregs), immature dendritic cells (DCs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs). This evidence concerns the gene CD8A and neoplasm.